Role of E. coli DNA in systemic inflammatory response syndrome

潘文东; 周红; 郑江; 夏培元; 秦孝建; 鲁永玲; 肖光夏

Your Location：

Home >

Browse articles >

Role of E. coli DNA in systemic inflammatory response syndrome

Updated：2026-03-12

- Role of E. coli DNA in systemic inflammatory response syndrome
- Role of E. coli DNA in systemic inflammatory response syndrome
- 解放军医学杂志（英文版） 2002年第3期页码：210-213
- Affiliations：
  
  1. Institute of Burn Research
  2. Southwest Hospital
  3. Third Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  National Natural Science Foundation of China （No. 30070299）
- DOI：
  中图分类号： R644
- 纸质出版：2002
- Accepted：
Scan QR Code
Role of E. coli DNA in systemic inflammatory response syndrome[J]. 解放军医学杂志（英文版）, 2002,(3):210-213.

[1]潘文东,周红,郑江,夏培元,秦孝建,鲁永玲,肖光夏.Role of E. coli DNA in systemic inflammatory response syndrome[J].Journal of Medical Colleges of PLA,2002(03):210-213.
Role of E. coli DNA in systemic inflammatory response syndrome[J]. 解放军医学杂志（英文版）, 2002,(3):210-213. DOI：

[1]潘文东,周红,郑江,夏培元,秦孝建,鲁永玲,肖光夏.Role of E. coli DNA in systemic inflammatory response syndrome[J].Journal of Medical Colleges of PLA,2002(03):210-213. DOI：

摘要

Abstract

<正> Objective: To investigate whether bacterial DNA involving in the pathogenesis of systemic inflammatory response syndrome （SIRS） and possible mechanism. Methods: Escherichia coli DNA （EC DNA） was extracted from Escherichia coli 25922 with alkaline lysis method. The mice mortality was observed after EC DNA was injected into mice via caudal vein. The changes of serum TNF-α and IL-6 levels in rats were measured with ELISA after rats were given EC DNA. Calf thymus DNA and lipopolysaccharide （LPS） were used as the control

respectively. Results: EC DNA led mice to death with notable dose-effect relationship （LD50 = 11. 51 mg/kg）

but CT DNA didn’t. The peak level of TNF-α was lower in EC DNA group than in LPS group （P<0. 05）

though the former reaching the peak I h earlier than the latter. However

they had coordinate ability to induce IL-6 release in rats

and no significant difference was seen in serum IL-6 peak level between 2 groups. Conclusion: EC DNA leads mice to death

and induces the increases of s

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据