Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases

于立新; 叶桂荣; 邓文锋; 付绍杰; 杜传福; 苗芸; 姚冰

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Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases

Updated：2026-03-12

- Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases
- Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases
- 解放军医学杂志（英文版） 2002年第3期页码：188-191
- Affiliations：
  
  1. Department of Kidney Transplantation
  2. Nanfang Hospital
  3. First Military Medical University
  4. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R699.2
- 纸质出版：2002
- Accepted：
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Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases[J]. 解放军医学杂志（英文版）, 2002,(3):188-191.

[1]于立新,叶桂荣,邓文锋,付绍杰,杜传福,苗芸,姚冰.Clinical observation of the effect of tacrolimus (Prograf) against renal allograft rejection in 294 cases[J].Journal of Medical Colleges of PLA,2002(03):188-191.
Clinical observation of the effect of tacrolimus （Prograf） against renal allograft rejection in 294 cases[J]. 解放军医学杂志（英文版）, 2002,(3):188-191. DOI：

[1]于立新,叶桂荣,邓文锋,付绍杰,杜传福,苗芸,姚冰.Clinical observation of the effect of tacrolimus (Prograf) against renal allograft rejection in 294 cases[J].Journal of Medical Colleges of PLA,2002(03):188-191. DOI：

摘要

Abstract

<正> Objective: To study the effect of tacrolimus （Prograf

FK506） in preventing renal allograft rejection. Methods: The curative effect

therapy index

toxicity and side effects of FK506 were observed in 294 renal transplant recipients among whom 268 received FK506 24 h after the operation and the other 26 with cyclosporine （CsA） developed acute rejection after transplantation and were given FK506 to replace methyl-prednisolone （MP） when the latter did not result. All the patients were given oral mycophenolate mofetil （MMF

1. 0 g/d） and meticorten （Pred

30 mg/d） 24 h later after operation. Results: In the 268 recipients previously mentioned

the incidence of acute rejection was 10. 45%

glycometabolism disorder 9. 33%

nervous system disturbance 1. 59%

liver function abnormality 2. 99%

nephrotoxicity 1. 87%

gastrointestinal disorder 17. 5%

cytomegalovirus （CMV） viremia 2. 99%

and non-CMV pulmonary infection 1. 59% （4/268）

with 1 fatal case for cerebral hemorrhage with normal allograft function and a

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