β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia

裴建明; 毕辉; 王跃民; 朱妙章; 周京军; 朱运龙

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β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia

Updated：2026-03-12

- β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia
- β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia
- 解放军医学杂志（英文版） 2003年第1期页码：1-7
- Affiliations：
  
  1. Department of Physiology
  2. Fourth Military Medical University
  3. Fourth Military Medical University Xi’an,710033
  4. ,China
- Author bio：
- Funds：
  
  Supported by a grant （01MB129）from the Department of Health,General Department of Logistic,PLA and a grant（CX01F001） from Fourth Military Medical University,Xi’an,China.
- DOI：
  中图分类号： R331.38
- 纸质出版：2003
- Accepted：
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β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia[J]. 解放军医学杂志（英文版）, 2003,(1):1-7.

[1]裴建明,毕辉,王跃民,朱妙章,周京军,朱运龙.β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia[J].Journal of Medical Colleges of PLA,2003(01):1-7.
β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia[J]. 解放军医学杂志（英文版）, 2003,(1):1-7. DOI：

[1]裴建明,毕辉,王跃民,朱妙章,周京军,朱运龙.β-adrenergic response modulated by κ-opioid receptor stimulation is attenuated in the cardiomyocytes of rats following chronic hypoxia[J].Journal of Medical Colleges of PLA,2003(01):1-7. DOI：

摘要

Abstract

<正> Objective: To study cross-talk between p-opioid receptor and β-adrenoceptor through determination of the intracellular calcium （ [ Ca2+ ]i ） and cAMP responses in ventricular myocytes of rats subjected to chronic hypoxia for 4 weeks. Methods: Electrically-induced [ Ca2+ ]i transient was measured in single right ventricular myocytes isolated from hearts of chronically hypoxic rats and the age-matched normoxic rats

by using a spectrofluorometric method. Results: β-adrenoceptor stimulation with isoproterenol increased the electrically-induced [ Ca + ]i transient and cAMP in myocytes of normoxic rats. U50

488H

a selective β-opioid receptor agonist

at dose （1 βmol/L） which itself had no effect on the [Ca2 + ]i transient and cAMP

significantly inhibited the effect of isoproterenol. This inhibition was completely abolished in the presence of nor-BNI

a selective K-opioid receptor antagonist. In the ventricular myocytes of chronically hypoxic rats

the inhibition of U50

488H on the increased [ Ca ]i tra

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