Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity

孟洁如; 赵宁; 颜真; 李玉松; 王文勇; 常耀明; 张英起

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Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity

Updated：2026-03-12

- Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity
- Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity
- 解放军医学杂志（英文版） 2002年第3期页码：222-226
- Affiliations：
  
  1. Biotechnology Centre
  2. Faculty of Preclinical Medicine
  3. Fourth Military Medical University
  4. ,China
  5. Department of Pathology
  6. Faculty of Aviation Medicine
- Author bio：
- Funds：
- DOI：
  中图分类号： R730.23
- 纸质出版：2002
- Accepted：
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Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity[J]. 解放军医学杂志（英文版）, 2002,(3):222-226.

[1]孟洁如,赵宁,颜真,李玉松,王文勇,常耀明,张英起.Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity[J].Journal of Medical Colleges of PLA,2002(03):222-226.
Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity[J]. 解放军医学杂志（英文版）, 2002,(3):222-226. DOI：

[1]孟洁如,赵宁,颜真,李玉松,王文勇,常耀明,张英起.Effects of Novel recombination human tumor necrosis factor on tumor cell growth and NF-KB activity[J].Journal of Medical Colleges of PLA,2002(03):222-226. DOI：

摘要

Abstract

<正> Objective: To investigate the relationship among the TNFRp55 and TNFRp75 expression in tumor cell lines in vitro

the suppression of nrhTNF on the tumor cell lines growth and the changing of NF-kB activity in the tumor cell lines. Methods:The expressions of TNFRs are studied by immunohistochemistry. The inhibition of nrhTNF to tumor cells was investigate by crystal violet assay. The changing of activity of NF-icB was evaluated by using immunohistochemistry and Western blot methods. Results: In tumor cell lines

positive rates of expression of TNFRp55 and TNFRp75 were 99% and 98. 8% respectively. There was no significant difference among various types of tumor cells （P>0. 05）. nrhTNF could inhibit the growth of SW480

SGC7901

8910

SMMC7721 and BEL-7402 cell lines in which NF-icB translocated into cytonuclei slightly. However

nrhTNF has no effects on A549

PLA801

Hela

Ecal09 and GRC-1 cell lines in which NF-kB translocated into cytonuclei obviously. Conclusion: The low degree of activating of NF-kB m

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