Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain

陈克强; 宋关鸿

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Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain

Updated：2026-03-12

- Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain
- Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain
- 解放军医学杂志（英文版） 2002年第1期页码：17-20
- Affiliations：
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- Funds：
  
  Supported by the National Natural Sciences Foundation of China （No. 39880041）
- DOI：
  中图分类号： R531.3
- 纸质出版：2002
- Accepted：
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Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain[J]. 解放军医学杂志（英文版）, 2002,(1):17-20.

[1]陈克强,,,,,,,,,,宋关鸿.Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain[J].Journal of Medical Colleges of PLA,2002(01):17-20.
Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain[J]. 解放军医学杂志（英文版）, 2002,(1):17-20. DOI：

[1]陈克强,,,,,,,,,,宋关鸿.Apoptosis of erythrocytic stage parasites of Plasmodium berghei chloro-quine-resistant strain[J].Journal of Medical Colleges of PLA,2002(01):17-20. DOI：

摘要

Abstract

<正>Objective: To explore the characteristics of crisis state at erythrocytic stage of Plasmodium berghei chloroquine-resistant （RC） strain. Methods: Agarose electrophoresis

optical and transmission electron microscopes were used. Patterns of genomic DNA structures and ultra structures of the erythrocytic parasites were observed in ICA mice （infected with the RC strain） during rising and declining of parasitemia. Results : During the declining parasitemia

the erythrocytic stage parasites of the RC strain showed round or o-val appearance with intact plasma membrane and shrank nuclei with no metabolic window

mitochondria or other membranaceous structures. Their DNA electrophoretogram revealed a ladder pattern which evidently differed from the parasites of the RC strain in the rising parasitemia and the chloroquine-sensitive （N） strain. Conclusion; The crisis state of the erythrocytic stage parasites of the P. berghei chloroquine-resistant （RC） strain is characterized by apoptosis.

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