<正>Objective: To investigate the association of changes in G and D cells in the antral mucosa with the production of gastrin and somatostatin during gastric ulcer and the healing process. Methods: Experimental gastric ulcer was induced with acetic acid in 42 Wistar rats and another 7 normal rats served as control. Changes in the production of gastrin and somatostatin in the plasma

gastric fluid and the antral tissues of the rats were measured by radio immunoassay

and the number and distribution of G and D cells were respectively determined by immunochemistry and Quantimet500 image analysis system. Results: In rats with gastric ulcer

the gastrin levels in the plasma

gastric fluid and the antral tissues increased while somatostatin levels were reduced

which were corrected in the healing process. Immunochemistry demonstrated the increase in the number of G cells in the antral tissues with decrease in D cell number

and the area covered by both cells shrank. The G cell to D cell number and area ratios were