<正>Objective: To investigate the effect of bone morphogenetic proteins （BMPs） on hematopoietic injury of acute radiation sickness in mice. Methods: Mice were subjected to whole-body 60Co γ ray irradiation

then bpBMP was put into spatium intermusculare or rhBMP-2m

PBK/ hBMP-2 -NIH3T3 cells were injected into abdominal cavity. The effect of BMPs on hematopoiesis including some hematological parameters

the survival rate of 30 d and formation of bone marrow CFU-GM colony were detected at postradiation. Results: pbBMP （purified bovine bone morphogenetic protein） increased the formation of bone marrow CFU-GM colony （P<0. 05） on d 10 after irradiation. rhBMP-2m increased the survival rate of mice irradiated by 7. 5 Gys Mice in control group died in 30 days

while 10%

15% and 35% mice survived when they were injected i. p. with 0. 5 mg

1. 0 mg and 2. 0 mg of rhBMP-2m respectively. All hematological parameters of treated mice were significantly higher than those of control group （P<0. 01）. PBK/ hBMP-2 -NIH3T3