Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice

朱瑾; 吴军; 陈希炜; 易绍萱; 罗高兴; 贺伟峰

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Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice

Updated：2026-03-12

- Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice
- Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice
- 解放军医学杂志（英文版） 2003年第1期页码：15-18
- Affiliations：
  
  1. Department of Otolarynology
  2. Southwest Hospital
  3. Third Medical University
  4. Institute of Burn Research
  5. Third Military Medical University
  6. Third Military Medical University Chongqing,400038
  7. ,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（No.39993430-2）;Key Project of Ministry of Science and Techology（No.96-920-20-10）;Academician Foundation of Chongqing （No.96-901-05-18）;Tackling Key Project of 1999（No.1999-6-40）
- DOI：
  中图分类号： R765.21
- 纸质出版：2003
- Accepted：
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Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice[J]. 解放军医学杂志（英文版）, 2003,(1):15-18.

[1]朱瑾,吴军,陈希炜,易绍萱,罗高兴,贺伟峰.Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice[J].Journal of Medical Colleges of PLA,2003(01):15-18.
Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice[J]. 解放军医学杂志（英文版）, 2003,(1):15-18. DOI：

[1]朱瑾,吴军,陈希炜,易绍萱,罗高兴,贺伟峰.Gene therapy for allergic rhinitis with recombinant adenovirus vector containing CTLA4Ig in mice[J].Journal of Medical Colleges of PLA,2003(01):15-18. DOI：

摘要

Abstract

<正> Objective: To examine the role of recombinant adenovirus vector containing CTLA4Ig gene（ Ad-CTLA4Ig） in the treatment of induced allergic rhinitis in mice. Methods: Allergic rhinitis was induced by sensitizing and challenging with ovalbumin （ OVA）. Ad-CTLA4Ig was intraperitoneally injected 30 min before OVA challenge. Adenovirus vector without inserted CTLA4Ig cDNA served as the control. The symptoms and morphological changes of nasal mucosa of each group were observed

and the serum levels of IgE against OVA were detected with ELISA. Results: There were no obvious symptoms and pathological changes in Ad-CTLA4Ig treated group

in which the serum OVA-specific IgE levels were significantly lower than that in control groups （P < 0. 05）. Conclusion: Ad-CTLA4Ig prevents and treats allergic rhinitis of mice

implying the possibility of the usage of Ad-CTLA4Ig against allergic rhinitis in clinic in future.

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