Influence of different gravitational environments on the mechanotrans-duction in osteoblasts

张舒; 吴兴裕; 李莹辉

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Influence of different gravitational environments on the mechanotrans-duction in osteoblasts

Updated：2026-03-12

- Influence of different gravitational environments on the mechanotrans-duction in osteoblasts
- Influence of different gravitational environments on the mechanotrans-duction in osteoblasts
- 解放军医学杂志（英文版） 2002年第2期页码：101-104
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the Research Foundation for Innovation project of FMMU（No. CX01A012）
- DOI：
  中图分类号： R363
- 纸质出版：2002
- Accepted：
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Influence of different gravitational environments on the mechanotrans-duction in osteoblasts[J]. 解放军医学杂志（英文版）, 2002,(2):101-104.

[1]张舒,,,,,,,,,,吴兴裕,,,,,,,,,,李莹辉.Influence of different gravitational environments on the mechanotrans-duction in osteoblasts[J].Journal of Medical Colleges of PLA,2002(02):101-104+124.
Influence of different gravitational environments on the mechanotrans-duction in osteoblasts[J]. 解放军医学杂志（英文版）, 2002,(2):101-104. DOI：

[1]张舒,,,,,,,,,,吴兴裕,,,,,,,,,,李莹辉.Influence of different gravitational environments on the mechanotrans-duction in osteoblasts[J].Journal of Medical Colleges of PLA,2002(02):101-104+124. DOI：

摘要

Abstract

<正>Objective: To observe the effects of different gravitational environments on release of prostaglandin E2 in rat calvarial osteoblasts induced by fluid shear stress （FSS） so that to investigate the influence of different gravity on mechanotransduction in osteoblasts. Methods: Osteoblasts were isolated from neonatal rat calvariae and then were set to three groups. Each was cultured in one gravitational environment; 1G terrestrial gravitational environment （control）

simulated weightlessness achieved by using clinostat and 3G gravitational environment achieved by using centrifuge for 60 h

then osteoblasts were treated with 0. 5 Pa or 1. 5 Pa FSS in a flow chamber for 1 h. The release of PGE2 in osteoblasts was determined. Results: In 1G gravitational environment

the release of PGE2 was significantly increased along with the sustaining of FSS treatments （P<0. 01）

but there was no remarkable difference between the responses to 0. 5 Pa FSS and 1. 5 Pa FSS （P>0. 05）. While in simulated weightlessness environ

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