Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats

李维方; 张光霁; 朱诚; 金由辛; 卢亦成

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Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats

Updated：2026-03-12

- Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats
- Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats
- 解放军医学杂志（英文版） 2003年第4期页码：242-245
- Affiliations：
  
  1. Department of Neurosurgery
  2. Changzheng Hospital
  3. Second Military Medical University
  4. ,Shanghai,200032
  5. State Key Laboratory of Molecular Biology
  6. Institute of Biochemistry and Cell Biology
  7. Shanghai Institute of Life Sciences
  8. Chinese Academy of Sceinces
- Author bio：
- Funds：
- DOI：
  中图分类号： R739.4
- 纸质出版：2003
- Accepted：
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Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J]. 解放军医学杂志（英文版）, 2003,(4):242-245.

[1]李维方,张光霁,朱诚,金由辛,卢亦成.Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J].Journal of Medical Colleges of PLA,2003(04):242-245.
Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J]. 解放军医学杂志（英文版）, 2003,(4):242-245. DOI：

[1]李维方,张光霁,朱诚,金由辛,卢亦成.Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J].Journal of Medical Colleges of PLA,2003(04):242-245. DOI：

摘要

Abstract

<正> Objective: To observe the inhibition of intracranial glioma tumorigenesis by vascular endothelial growth factor （VEGF） antisense oligodeoxynucleotide （ODN） in rats. Methods: Totally 20 μ1 Hank’s liquid containing 1×106 C6 glioma cells was seeded into rat right caudate putaraen in high-flow microinfusion with stereotactic technique. VEGF antisense ODN was simultaneously used with glioma cell. Each rat of the treated group Ⅰ and the treated group Ⅱ was treated with 1 000 μmol/L VEGF antisense ODN. Each rat of the treated group Ⅲ and the treated group Ⅳ was treated with 2 000 μmol/L VEGF antisense ODN. The experimental periods of the treated group Ⅰ

the treated group Ⅲ and the control group Ⅰ were 2 weeks

those of the treated group Ⅱ

the treated group Ⅳ and the control group Ⅱ were 3 weeks. Before sacrifice

MRI was performed on each rat. Tumor magnitude and pathologic examination were detected after samples were dissected. Results: The survival state of all treated rats was better

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