<正>Objective: To study the changes of serum level of soluble interleukin-2 receptor （sIL-2R） in patients with mechanical trauma and the relationship between sIL-2R serum level and injury severity score （ISS）

and to explore the mechanism of changes and clinical significances of sIL-2R. Methods: According to the criterion of ISS

50 patients with mechanical trauma were divided into mild degree group

severe degree group and extremely severe degree group. Twenty-five of those were dynamically observed for 12 d. Blood samples of all the patients were obtained within 24 h

and ond3

d5

d7

d9 and d 12 in dynamically observed patients. The serum concentration of sIL-2R was assayed by ELISA. Results: Level of sIL-2R was significantly higher in patients with trauma than that in healthy persons within 24 h （P<0. 05）. Dynamical observation showed curving changes of sIL-2R with increasing in early stage and decreasing later. The climax of sIL-2R appeared earlier in mild group than that in severe degree group and extrem