Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer

王钢; 王晓慧; 夏冰; 陈光椿; 卢建

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Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer

Updated：2026-03-12

- Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer
- Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer
- 解放军医学杂志（英文版） 2002年第2期页码：147-151
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 39670300）
- DOI：
  中图分类号： R737.25
- 纸质出版：2002
- Accepted：
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Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer[J]. 解放军医学杂志（英文版）, 2002,(2):147-151.

[1]王钢,,,,,,,,,,王晓慧,,,,,,,,,,夏冰,,,,,,,,,,陈光椿,,,,,,,,,,卢建.Study on relationship between polymorphism of hAR gene (CAG)n micro-satellite and prostate cancer[J].Journal of Medical Colleges of PLA,2002(02):147-151.
Study on relationship between polymorphism of hAR gene （CAG）n micro-satellite and prostate cancer[J]. 解放军医学杂志（英文版）, 2002,(2):147-151. DOI：

[1]王钢,,,,,,,,,,王晓慧,,,,,,,,,,夏冰,,,,,,,,,,陈光椿,,,,,,,,,,卢建.Study on relationship between polymorphism of hAR gene (CAG)n micro-satellite and prostate cancer[J].Journal of Medical Colleges of PLA,2002(02):147-151. DOI：

摘要

Abstract

<正>Objective: To study the relationship between the polymorphic （CAG）n micro-satellite of human androgen receptor （hAR） gene and prostate cancer （PCa）. Methods: The number of （CAG）n repeats in 107 normal males were measured by a two-step [α-32P]-dCTP incorporated asymmetric polymeric chain reaction （PCR）

and the （CAG）n repeats of both malignant and nonmalignant prostate cells in fixed paraffin-embedded tissue （PET） specimen from 36 case of PCa were determined by sequence analysis. Results: The repeats of polymorphic （CAG） n among normal men ranged from 11 to 29

and the most frequent repeat was 22（18. 69%）

with 23（14. 02%）

24（10. 28%） and 21（10. 28%） being less frequent. The （CAG）n repeats of malignant prostate cells equaled to that of nonmalignant adjacent prostate tissue cells from the same PET specimen in all 36 PCa

and the （CAG）n repeats in 36 PCa which ranged from 16 to 22 were shorter than that in normal males significantly （P<0. 05）

while no significant difference in （CAG）n repeats among variou

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