Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes

邓安梅; 仲人前; 陈孙孝; 周晔; 孔宪涛

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Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes

Updated：2026-03-12

- Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes
- Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes
- 解放军医学杂志（英文版） 2002年第1期页码：51-53
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 39970684）
- DOI：
  中图分类号： R758.63
- 纸质出版：2002
- Accepted：
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Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes[J]. 解放军医学杂志（英文版）, 2002,(1):51-53.

[1]邓安梅,,,,,,,,,,仲人前,,,,,,,,,,陈孙孝,,,,,,,,,,周晔,,,,,,,,,,孔宪涛.Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes[J].Journal of Medical Colleges of PLA,2002(01):51-53.
Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes[J]. 解放军医学杂志（英文版）, 2002,(1):51-53. DOI：

[1]邓安梅,,,,,,,,,,仲人前,,,,,,,,,,陈孙孝,,,,,,,,,,周晔,,,,,,,,,,孔宪涛.Lymphocytes in patients with psoriasis promote proliferation of ker-atinocytes[J].Journal of Medical Colleges of PLA,2002(01):51-53. DOI：

摘要

Abstract

<正>Objective: To analyze the effect of lymphocytes on proliferation of keratinocytes in patients with psoriasis. Methods: Lymphocytes in lesion and peripheral blood were isolated and amplified

then cultured together with normal keratinocytes. By MTT method

the living cells were quantified in the mixed culture. Results: Compared with normal controls

lymphocytes from lesion and peripheral blood of psoriasis both promote the proliferation of keratinocytes （P<0. 01 and P<0. 05 respectively）. The concentrations of IL-2 and IFN-7 in the mixture of lesion lymphocytes and keratinocytes were significantly higher than that of controls. Tripterygium glycosides inhibited this promotion. Conclusion: Lymphocytes in patients with psoriasis （mainly Th1 cell） play an important role in proliferation of keratinocytes. This psoriasis cell model is useful for studies on signal transduction in psoriasis.

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