Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma

付萌; 张衍国; 刘玉峰; 陈妍; 王秋枫; 李巍

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Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma

Updated：2026-03-12

- Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma
- Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma
- 解放军医学杂志（英文版） 2002年第1期页码：5-9
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  中图分类号： R739.5
- 纸质出版：2002
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Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma[J]. 解放军医学杂志（英文版）, 2002,(1):5-9.

[1]付萌,,,,,,,,,,张衍国,,,,,,,,,,刘玉峰,,,,,,,,,,陈妍,,,,,,,,,,王秋枫,,,,,,,,,,李巍.Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma[J].Journal of Medical Colleges of PLA,2002(01):5-9.
Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma[J]. 解放军医学杂志（英文版）, 2002,(1):5-9. DOI：

[1]付萌,,,,,,,,,,张衍国,,,,,,,,,,刘玉峰,,,,,,,,,,陈妍,,,,,,,,,,王秋枫,,,,,,,,,,李巍.Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma[J].Journal of Medical Colleges of PLA,2002(01):5-9. DOI：

摘要

Abstract

<正>Objective: To investigate the influence of anti-keratin autoantibodies （AK auto Abs） on telom-erase activity of squamous cell carcinoma cultured in vitro and the mechanisms of the inhibitory effects of AK auto Abs on squamous cell carcinoma. Methods: Influence of AK auto Abs on the proliferation of Tca cells was observed by MTT colorimetry. Telomerase activity of cultured Tca cells and human keratinocytes was determined by telomeric repeat amplication protocol-ELISA （TRAP-ELISA） and polyacrylamide gel elec-trophoresis （PAGE）. After being treated with AK auto Abs for 36 h at a concentration of 4

16 mg/L respectively

the changes of telomerase activity of Tea cells were also detected by TRAP-ELISA and PAGE. Results: MTT colorimetric determination showed that the capacity of proliferation of Tca cells correlated negatively with the concentration of AK auto Abs （r= -0. 74

P<0. 01）. TRAP-ELISA and PAGE showed that telomerase activity of Tca cells increased significantly compared to that of cultured human

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