Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion

张巍; 万琪; 刘勇红

Your Location：

Home >

Browse articles >

Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion

Updated：2026-03-12

- Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion
- Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion
- 解放军医学杂志（英文版） 2002年第4期页码：270-275
- Affiliations：
  
  1. Department of Neurology
  2. Xijing Hospital
  3. Fourth Military Medical University
  4. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R741
- 纸质出版：2002
- Accepted：
Scan QR Code
Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion[J]. 解放军医学杂志（英文版）, 2002,(4):270-275.

[1]张巍,万琪,刘勇红.Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion[J].Journal of Medical Colleges of PLA,2002(04):270-275.
Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion[J]. 解放军医学杂志（英文版）, 2002,(4):270-275. DOI：

[1]张巍,万琪,刘勇红.Single-strand DNA damages and its relationship with morphological change of neurons at early stage of rat cerebral ischemia/reperf usion[J].Journal of Medical Colleges of PLA,2002(04):270-275. DOI：

摘要

Abstract

<正> Objective: To discuss the DNA-strand breaks at early stage of middle cerebral artery occlusion/ reperfusion （MCAO/R）. Methods: Neurons number and morphologic change were observed by Nissl stain method

and DNA strand breaks were in situ detected by using DNA polymerase- I Klenow fragment-mediated nick end-labelling method （Klenow method）. Results: Six hours after reperfusion

a few neurons in damaged regions appeared morphologic changes while a few Klenow-positive cells were detected （P<0. 01）. Twenty-four hours after reperfusion lots of neurons showed morphologic change while the number of Klenow-positive cells immediately and remarkably increased （P<0. 01）. Seventy-two hours after reperfusion the number of neurons decreased significantly and the number of Klenow-positive cells was also less than that in 24 h （P<0. 05）. Conclusion: ① 24 h after reperfusion when the number of Klenow-positive cells reached peak value

DNA single-strand breaks （SSBs） took place in many Klenow-positive cells

and presumed

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据