Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas

房殿春; 罗元辉

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Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas

Updated：2026-03-12

- Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas
- Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas
- 解放军医学杂志（英文版） 2002年第2期页码：143-146
- Affiliations：
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China （No. 30070043） , and “the Tenth five-year Plan”Scientific Research Foundation of Chinese PLA （No. 01Z075）
- DOI：
  中图分类号： R735.2
- 纸质出版：2002
- Accepted：
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Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas[J]. 解放军医学杂志（英文版）, 2002,(2):143-146.

[1]房殿春,,,,,,,,,,罗元辉.Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas[J].Journal of Medical Colleges of PLA,2002(02):143-146.
Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas[J]. 解放军医学杂志（英文版）, 2002,(2):143-146. DOI：

[1]房殿春,,,,,,,,,,罗元辉.Methylation of hMLH1 and hMSH2 promoters in gastric carcinomas[J].Journal of Medical Colleges of PLA,2002(02):143-146. DOI：

摘要

Abstract

<正>Objective: To study the correlation of the methylation of the promoters of hMLH1 and hMSH2 with microsatellite instability （MSI） in the tissues of gastric carcinomas. Methods: A total of 68 sporadic cases of gastric carcinoma were studied. Ten specimens of normal gastric mucosa served as control. Methylation of hMLHl and hMSH2 was observed with methylation-specific PCR

and MSI analyzed with PCR-based techniques. Results: No methylation of hMLHl and hMSH2 was found in 10 specimens of normal gastric mucosa. Methylation of hMLHl was detected in 11 cases （16. 2%） of gastric cancers and MSI in at least one locus was found in 17 cases （25%） of the 68 with aid of 5 microsatellite markers

in which eight were MSI-H （≥2loci showed instability） nine MSI-L （only one locus showed instability）

and fifty-one were MSS （no instability at any marker）. The frequency of methylation was significantly high in MSI-H （87. 5%） than in MSI-L （11.1%） and MSS （5. 9%）. CP<0. 01 - 0. 001) but there was no difference of methylatio

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