Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity

李国锋; 神山文男; 刘立捷; 山本昌; 陈建海

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Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity

Updated：2026-03-12

- Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity
- Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity
- 解放军医学杂志（英文版） 2002年第2期页码：152-156
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  中图分类号： R96
- 纸质出版：2002
- Accepted：
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Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity[J]. 解放军医学杂志（英文版）, 2002,(2):152-156.

[1]李国锋,,,,,,,,,,神山文男,,,,,,,,,,刘立捷,,,,,,,,,,山本昌,,,,,,,,,,陈建海.Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity[J].Journal of Medical Colleges of PLA,2002(02):152-156.
Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity[J]. 解放军医学杂志（英文版）, 2002,(2):152-156. DOI：

[1]李国锋,,,,,,,,,,神山文男,,,,,,,,,,刘立捷,,,,,,,,,,山本昌,,,,,,,,,,陈建海.Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity[J].Journal of Medical Colleges of PLA,2002(02):152-156. DOI：

摘要

Abstract

<正>Objectives: To evaluate the barrier function of different skin layers in the process of percutaneous drug absorption. Methods: In vitro permeability via intact or stripped skin of 6 drugs （5-fluorouracil

theo-phylline

hydroquinone

barbital

isosorbide dinitrate and ketoprofen） with a wide span of lipophilicity were investigated in the patch dosage forms. Results: Characteristic parabolic relations was observed between the permeability （Kp

cm/h） of the drugs with different lipophilicity and their LogPc via either intact or stripped skin. However

due to the absence of the stratum corneum

increased Kp ratio for the tested drugs was proportional to their solubility in water other than their LogKp. When isopropyl myristate was used as absorption promoter of the drugs

the parabolic relationship no longer existed. For the intact skin

increase of Kp ratio of the drugs was enhanced resulting from IPM as drug’s LogPc decreased. On the other hand

in the case of stripped skin

this enhancement was positivel

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