Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines

赵晓艾; 刘陕西

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Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines

Updated：2026-03-12

- Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines
- Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines
- 解放军医学杂志（英文版） 2003年第3期页码：154-158
- Affiliations：
  
  1. Department of Hematology
  2. First Hospital
  3. Xi’an Jiaotong University
  4. ,China
- Author bio：
- Funds：
  
  Supported by Chinese Medicine Foundation of Shaanxi Province（No.1999002）
- DOI：
  中图分类号： R733.7
- 纸质出版：2003
- Accepted：
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Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines[J]. 解放军医学杂志（英文版）, 2003,(3):154-158.

[1]赵晓艾,刘陕西.Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines[J].Journal of Medical Colleges of PLA,2003(03):154-158.
Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines[J]. 解放军医学杂志（英文版）, 2003,(3):154-158. DOI：

[1]赵晓艾,刘陕西.Effect of arsenic sulfide on tissue factor expression in acute promyelocytic leukemia cell lines[J].Journal of Medical Colleges of PLA,2003(03):154-158. DOI：

摘要

Abstract

正

Objective: To investigate the effect of arsenic sulfide （tetra-arsenic tetra-suffide As

; diarsenic trisulfideAs

）on tissue factor （TF） expression and procoagulant activity （PCA） of acute promyelocytic leukemia（APL） celllines （NB

and MR

） and the basic mechanism of their role. Methods: NB

and MR

cells were respectively treatedwith As

and Cyclohexamide（CHX）. PCA of the cells was detected using one-stage clotting assay.TF antigen was detected by ELISA. TF and PML/RARα fusion gene mRNA by semi-quantitive RT-PCR. The PCA andTF antigen of HL-60 and K562 cells were also examined. Results: The PCA and TF antigen level in NB

and MR

cells were significantly higher than that in HL-60 and K562 cells. Both As

and As

can down-regulate the TF anti-gen

TF mRNA transcription and membrane PCA of NB

and MR

cells in vitro in a time-dependent manner. The roleof As

was stronger than that of As

. Both As

and As

had no effect on PML/RAR

fusion gene

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