Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium

董书强; 张宝仁; 梅举; 徐志云; 邹良建; 黄盛东

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Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium

Updated：2026-03-12

- Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium
- Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium
- 解放军医学杂志（英文版） 2002年第2期页码：96-100
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 39970735）
- DOI：
  中图分类号： R541
- 纸质出版：2002
- Accepted：
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Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium[J]. 解放军医学杂志（英文版）, 2002,(2):96-100.

[1]董书强,,,,,,,,,,张宝仁,,,,,,,,,,梅举,,,,,,,,,,徐志云,,,,,,,,,,邹良建,,,,,,,,,,黄盛东.Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium[J].Journal of Medical Colleges of PLA,2002(02):96-100.
Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium[J]. 解放军医学杂志（英文版）, 2002,(2):96-100. DOI：

[1]董书强,,,,,,,,,,张宝仁,,,,,,,,,,梅举,,,,,,,,,,徐志云,,,,,,,,,,邹良建,,,,,,,,,,黄盛东.Angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium[J].Journal of Medical Colleges of PLA,2002(02):96-100. DOI：

摘要

Abstract

Objective: To study the angiogenesis effects of adenovirus-mediated gene transfer of VEGF-B on chronic ischemic myocardium. Methods: Domestic pigs underwent thoracotomy and placement of an ameroid constrictor on the circumflex coronary artery. Four weeks later

Ad. VEGF-B

Ad. LacZ or PBS were administrated directly into the myocardium at 10 sites in the circumflex distribution （109 PFU or 100 μl） according to groups. Echocardiography and ex vivo coronary angiography were performed. The injection sites around myocardium were harvested and subjected to histological analysis and immunochemical staining. Results: E-chocardiography assessment 4 weeks after vector administration demonstrated significant improvement of regional wall systolic function. Collateral vessel development assessed by angiography was also significantly greater in Ad. VEGF-B animals than that in control animals. Vascular density analysis revealed a mean of 43±5 neovessels per high-power field in Ad. VEGF-B group versus 19±4 and 17±6 in

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