Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells

陈惠; 孙晓莉; 刘志红; 张生勇; 药立波

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Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells

Updated：2026-03-12

- Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells
- Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells
- 解放军医学杂志（英文版） 2003年第4期页码：246-250
- Affiliations：
  
  1. Department of Chemistry
  2. Department of Biochemistry & Molecular Biology
  3. School of Basic Medicine
  4. Fourth Military Medical University
  5. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R73-3
- 纸质出版：2003
- Accepted：
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Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells[J]. 解放军医学杂志（英文版）, 2003,(4):246-250.

[1]陈惠,孙晓莉,刘志红,张生勇,药立波.Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells[J].Journal of Medical Colleges of PLA,2003(04):246-250.
Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells[J]. 解放军医学杂志（英文版）, 2003,(4):246-250. DOI：

[1]陈惠,孙晓莉,刘志红,张生勇,药立波.Preparation of six quinazoline schiff bases and their inhibitory effect on HHCC and Bcap-37 cells[J].Journal of Medical Colleges of PLA,2003(04):246-250. DOI：

摘要

Abstract

<正> Objective: To prepare six quinazoline schiff bases by six steps of chemistry organic synthesis and test their inhibitory effect on hepatomacellular carcinoma cells HHCC and mammary cancer cell Bcap-37

furthmore

to compare their antitumor activities on these two kinds of cells. Methods: 2-Amino-5-nitro-benzylcarbonitrile was the initial material

and it was under the reaction of hydrolysis

ring-closing

halogenation

addition

reduction and substitution in turn to get the six quinazoline schiff bases

MTT method was adopted to compare their anticancer activities against the two cancer cells. Result and Conclusion: Six 6-imine-4-halo substituted anilinoquinozolines were prepared. The anti-cancer activities against both HHCC and Bcap-37were found

furthermore

they have more potency that on HHCC than on Bcap-37. In the six compounds

the schiff base Ⅵ is the most potent compound.

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