In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines

陈思宇; 刘陕西; 李信民

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In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines

Updated：2026-03-12

- In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines
- In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines
- 解放军医学杂志（英文版） 2002年第1期页码：34-38
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the Foundation of Chinese Medicine Administration of Shaanxi Province （1999-02, 2001-008）.
- DOI：
  中图分类号： R733.71
- 纸质出版：2002
- Accepted：
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In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines[J]. 解放军医学杂志（英文版）, 2002,(1):34-38.

[1]陈思宇,,,,,,,,,,刘陕西,,,,,,,,,,李信民.In vitro study on arsenic sulfide (realgar)-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines[J].Journal of Medical Colleges of PLA,2002(01):34-38.
In vitro study on arsenic sulfide （realgar）-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines[J]. 解放军医学杂志（英文版）, 2002,(1):34-38. DOI：

[1]陈思宇,,,,,,,,,,刘陕西,,,,,,,,,,李信民.In vitro study on arsenic sulfide (realgar)-induced apoptosis of retinoic acid susceptible or resistant acute promyelocytic leukemia cell lines[J].Journal of Medical Colleges of PLA,2002(01):34-38. DOI：

摘要

Abstract

<正>Objective: To further understand the possible mechanisms of arsenic sulfide （realgar） in the treatment of acute promyelocytic leukemia （APL）. Methods: All-trans retinoic acid （ATRA）-susceptible APL cell line （NB4 cells） and ATRA-resistant APL cell line （MR2 subclone） were used as models in vitro. At various times after incubated with various concentrations of realgar

NB4 and MR2 cells were observed by cell viability

cell proliferation and cell morphology; cell cycle and the expression of Annexin V were assayed by flow cytometry. Results: Cell viability and proliferation of NB4 and MR2 cells were inhibited after the treatment

to some extent

in a dose and time dependent manner. 177 - 711g/L of realgar treated NB4 and MR2 cell presented morphologically some features of apoptotic cells such as intact cell membrane

chromatin condensation and nuclear fragmentation

apoptosis body could be found by electron microscopy as well. Sub-Gl cells and cell cycle arrest were observed by flow cytometry. The proport

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