Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction

董安平; 马爱群; 韩克; 杨春; 蔡平; 蒋文慧

Your Location：

Home >

Browse articles >

Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction

Updated：2026-03-12

- Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction
- Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction
- 解放军医学杂志（英文版） 2003年第4期页码：251-254
- Affiliations：
  
  1. Cardiovascular Research Institute
  2. First Hospital
  3. Xi’an Jiaotong University
  4. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R542.22
- 纸质出版：2003
- Accepted：
Scan QR Code
Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction[J]. 解放军医学杂志（英文版）, 2003,(4):251-254.

[1]董安平,马爱群,韩克,杨春,蔡平,蒋文慧.Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction[J].Journal of Medical Colleges of PLA,2003(04):251-254.
Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction[J]. 解放军医学杂志（英文版）, 2003,(4):251-254. DOI：

[1]董安平,马爱群,韩克,杨春,蔡平,蒋文慧.Granulocyte-macrophage colony stimulating factor improves cardiac function in rabbits following myocardial infarction[J].Journal of Medical Colleges of PLA,2003(04):251-254. DOI：

摘要

Abstract

<正> Objective: To investigate the therapeutic potency of recombinant human Granulocyte-Macrophage Colony-Stimulating Factor （GM-CSF） in a rabbit myocardial infarction model. Methods: A myocardial infarction was created by the ligation of the major ventricular branch of the left coronary artery in rabbits. After myocardial infarction

the animals were randomly assigned to GM-CSF treatment group

untreated groups and sham-operated group. The rabbits of the treated group were injected into GM-CSF by subcutaneous administration

10 μg/kg/day

once a day for 5 days. The untreated and sham-operated group received a equal saline in the same manner as treated group. Six weeks later echocardiography and haemodynamic assessment were undertaken to assesse cardiac function. The size of the infarct region of the heart were also studied. Results: The untreated group exhibited significant higher left ventricle end-diastolic pressure

higher central venous pressure

and with significant lower mean blood pressure

lower pe

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据