Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro

郭乔楠; 赵建华; 卢佳友

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Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro

Updated：2026-03-12

- Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro
- Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro
- 解放军医学杂志（英文版） 2003年第5期页码：277-282
- Affiliations：
  
  1. Institute of Pathology
  2. Southwest Hospital
  3. Third Military Medical University
  4. ,Chongqing,400042
  5. Department of Orthopaedics
  6. Daping Hospital
- Author bio：
- Funds：
- DOI：
  中图分类号： R687
- 纸质出版：2003
- Accepted：
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Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro[J]. 解放军医学杂志（英文版）, 2003,(5):277-282.

[1]郭乔楠,赵建华,卢佳友.Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro[J].Journal of Medical Colleges of PLA,2003(05):277-282.
Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro[J]. 解放军医学杂志（英文版）, 2003,(5):277-282. DOI：

[1]郭乔楠,赵建华,卢佳友.Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro[J].Journal of Medical Colleges of PLA,2003(05):277-282. DOI：

摘要

Abstract

<正> Objective: To evaluate the osteocompatibility of D

L-polylactic/hydroxyapatite/decalcifying bone matrix （PDLLA/HA/DBM）

and compare with PDLLA and DBM. Methods: Human primary osteoblasts isolated from the femoral head of patients were inoculated onto PDLLA/HA/DBM

PLA and DBM respectively. The proliferation rate and collagen Ⅰ expression were detected. The interface between biomaterial and osteoblasts was investigated with phase contrast microscopy and electron scanning microscopy. Results: Best proliferation rate was observed with the PDLLA/HA/DBM and followed by DBM and PLA

suggesting that PDLLA/HA/DBM satisfying most requirements for the cultivation of human osteoblasts. Scanning electron microscopy showed the morphology of osteoblasts was correlated with the proliferation data. The cells

well spread and flattened

were attached closely on the surface of biomaterial with an arched structure and had normal morphology. The extracellular collagenous matrixs covered the surface of biomaterial and pa

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