Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats

骆纯; 卢亦成; 朱诚; 江基尧

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Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats

Updated：2026-03-12

- Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats
- Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats
- 解放军医学杂志（英文版） 2003年第2期页码：77-80
- Affiliations：
  
  1. Department of Neurosurgery
  2. Changzheng Hospital
  3. Second Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  Supported by Directive Subject of Chinese PLA（No.96L036）
- DOI：
  中图分类号： R651.1
- 纸质出版：2003
- Accepted：
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Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats[J]. 解放军医学杂志（英文版）, 2003,(2):77-80.

[1]骆纯,卢亦成,朱诚,江基尧.Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats[J].Journal of Medical Colleges of PLA,2003(02):77-80.
Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats[J]. 解放军医学杂志（英文版）, 2003,(2):77-80. DOI：

[1]骆纯,卢亦成,朱诚,江基尧.Effect of U-74389G on apoptosis and bcl-2 expression following traumatic brain injury in rats[J].Journal of Medical Colleges of PLA,2003(02):77-80. DOI：

摘要

Abstract

<正> Objective: To investigate the relationship between oxidative stress and apoptosis and bcl-2 expression fol-lowing traumatic brain injury （TBI）. Methods: Male Sprague-Dawley ras were subjected to lateral fluid percussionbrain injury （FPBI） of moderate severity. U-74389G （20 mg/kg） were administered intravenously before FPBI. Theneurological functions were measured by beam-walk task （BWT） and beam-balance task （BBT）. In addition to mor-phological evidence of apoptosis

TUNEL histochemistry was used to identify DNA fragmentation in situ with both lightand electron microscopic levels. The internucleosomal fragments of DNA in apoptotic cells were examined using agarose

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