Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure

钟萍; 李志樑; 吴宏超; 唐朝枢; 陆青

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Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure

Updated：2026-03-12

- Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure
- Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure
- 解放军医学杂志（英文版） 2003年第4期页码：258-261
- Affiliations：
  
  1. Department of Cardiology
  2. Zhujiang Hospital
  3. First Military Medical University
  4. ,Beijing,100034
  5. Instisute of Cardiology
  6. First Hospital
  7. Beijing University
- Author bio：
- Funds：
  
  This study is a subitem of Key Basic Research and Development Project of National "973" Program of China （G200056905 ）
- DOI：
  中图分类号： R541.6
- 纸质出版：2003
- Accepted：
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Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure[J]. 解放军医学杂志（英文版）, 2003,(4):258-261.

[1]钟萍,李志樑,吴宏超,唐朝枢,陆青.Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure[J].Journal of Medical Colleges of PLA,2003(04):258-261.
Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure[J]. 解放军医学杂志（英文版）, 2003,(4):258-261. DOI：

[1]钟萍,李志樑,吴宏超,唐朝枢,陆青.Relationship of the plasma urotensin Ⅱ with proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure[J].Journal of Medical Colleges of PLA,2003(04):258-261. DOI：

摘要

Abstract

<正> Objective: To understand the role of urotensin Ⅱ （ U Ⅱ ） and proadrenomedullin N-terminal 20 peptide （ PAMP）

a fragment of proadrenomedullin （ proADM ） possessing biological activity

in the pathophysiological process of congestive heart failure （CHF） by observing the variation of their plasma levels and exploring their interrelations. Methods: Plasma U Ⅱ and PAMP levels were measured by radioimmunoassay in 52 patients with CHF and 14 healthy subjects. Left ventricular ejection fraction （LVEF） and the ratio of E/A were determined by echocardiography. Results: The plasma U Ⅱ level was significantly lower in patients with CHF than the healthy subjects （1.5±1.0 pg/ml vs 4. 3±1.2 pg/ml

P < 0.05）

while plasma PAMP level was significantly higher in the former group （30. 6±5. 8 pg/ml vs 21.0±6.6 pg/ml P < 0. 05 ）. The levels of U Ⅱ and PAMP were parallel with the severity of CHF

and significant correlation of plasma levels of U Ⅱ with LVEF （r=0.530

P=0.000） and the ratio of E/A (r=0.618

P = 0.

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