Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids

张伟; Hans Jrg Hacker; Maria Mildenberger; Claus H.Schrder; 苏勤

Your Location：

Home >

Browse articles >

Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids

Updated：2026-03-12

- Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids
- Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids
- 解放军医学杂志（英文版） 2003年第3期页码：2-174
- Affiliations：
  
  1. Department of Pathology
  2. Tangdu Hospital
  3. Fourth Military Medical University
  4. ,Germany
  5. Department of Virus-Host Interactions
  6. Deutsches Krebsforschungszentrum Heidelberg
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（No.30171052）
- DOI：
  中图分类号： R512.6
- 纸质出版：2003
- Accepted：
Scan QR Code
Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J]. 解放军医学杂志（英文版）, 2003,(3):2-174.

[1]张伟,Hans Jrg Hacker,Maria Mildenberger,Claus H.Schrder,苏勤.Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J].Journal of Medical Colleges of PLA,2003(03):2-174.
Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J]. 解放军医学杂志（英文版）, 2003,(3):2-174. DOI：

[1]张伟,Hans Jrg Hacker,Maria Mildenberger,Claus H.Schrder,苏勤.Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids[J].Journal of Medical Colleges of PLA,2003(03):2-174. DOI：

摘要

Abstract

<正> To monitor the progression of lamivudine therapy by demonstrating HBV DNAs and RNAs in the serum of achronically infected patient. Viral nucleic acids were exracted from serum samples taken during a 14-week treatmentperiod and analyzed via competitive PCR and RT/PCR. The dynamic changes in the amount as well as in the structurescan monitor therapy process very well. Our study indicated the level of polyadenylated viral RNA can be a marker forexpression in general

and the appearance of replicative intermediates as a mirror of the mode of action of an antiviraldrug.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据