Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation

杜永峰; 万明习; 周晓东

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Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation

Updated：2026-03-12

- Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation
- Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation
- 解放军医学杂志（英文版） 2003年第2期页码：109-114
- Affiliations：
  
  1. Department of Biomedical Engineering
  2. Xi’an Jiaotong University
  3. ,Xi’an,710033
  4. Ultrasound Division
  5. Xijing Hospital
  6. Fourth Military Medical University
- Author bio：
- Funds：
  
  Supported by the High Technology Research Development Program of China（863 Program,No.2001AA218031）and the National Natural Science Foundation of China（No.30270404）.
- DOI：
  中图分类号： R445.1
- 纸质出版：2003
- Accepted：
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Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation[J]. 解放军医学杂志（英文版）, 2003,(2):109-114.

[1]杜永峰,万明习,周晓东.Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation[J].Journal of Medical Colleges of PLA,2003(02):109-114.
Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation[J]. 解放军医学杂志（英文版）, 2003,(2):109-114. DOI：

[1]杜永峰,万明习,周晓东.Microbubble ultrasound contrast agent with three esters and carboxylic methyl cellulose as main shell materials: Its preparation and imaging evaluation[J].Journal of Medical Colleges of PLA,2003(02):109-114. DOI：

摘要

Abstract

<正> Objective: To study on the preparation process of a new surfactant-based microbubble ultrasound contrastagent and to evaluate its contrast effects in vivo. Methods: Microbubble ultrasound contrast agent with three ester sur-factants and other additives as its shell materials was prepared by sonication. Sulfur hexafluoride was adopted as the in-ner gas of the microbubbles. New methods through the combination of optical microscope and some softwares were usedto measure the size distribution and the concentration of the microbubbles. Some parameters such as the pH value of thephosphate buffer

quantity of the carboxylic methyl cellulose in the shell materials

selection of the ultrasound powerand process time

were studied. Six hybirded dogs were used to verify the in vivo contrast imaging of the contrast agentusing second harmonic power Doppler modality. Safety and persistent time of the agent inner animal body were also in-

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