Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease

吴赛珠; 李曦; 郑华; 郭志刚; 赖文岩; 吴迎星

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Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease

Updated：2026-03-12

- Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease
- Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease
- 解放军医学杂志（英文版） 2003年第4期页码：255-257
- Affiliations：
  
  1. Department of Cardiology
  2. Nanfang Hospital
  3. First Military Medical University
  4. ,China
  5. Department of Basic Medical Sciences
- Author bio：
- Funds：
  
  Supported by the Key Basic Research and Development Project of National "973" Program of China （G200057008）;the Foundation for University Leading Teachers Sponsored by the Ministry of Education of China, and by Funds for Key Natural Science Research of
- DOI：
  中图分类号： R541.4
- 纸质出版：2003
- Accepted：
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Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease[J]. 解放军医学杂志（英文版）, 2003,(4):255-257.

[1]吴赛珠,李曦,郑华,郭志刚,赖文岩,吴迎星.Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease[J].Journal of Medical Colleges of PLA,2003(04):255-257+266.
Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease[J]. 解放军医学杂志（英文版）, 2003,(4):255-257. DOI：

[1]吴赛珠,李曦,郑华,郭志刚,赖文岩,吴迎星.Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease[J].Journal of Medical Colleges of PLA,2003(04):255-257+266. DOI：

摘要

Abstract

<正> Objective: To investigate the relationship between estrogen receptor （ER） gene and the clinical indexes associated with coronary heart disease （ CHD）. Methods: By means of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）

we analyzed ER gene polymorphism in 84 CHD patients and 61 healthy subjects and non-CHD inpatients. The clinical indexes associated with CHD were analyzed in relation to the three ER genotypes. Results: There were significant differences in the incidence of hypertension （58.62% ）

fibrinogen （Fib） concentration （3. 5±0. 8 g/L）

body mass index （BMI

25. 1±3. 2）

HDL-C concentration （1.0±0. 2 mmol/L） between PP genotype group and other genotype groups （P <0. 05）. Conclusion: ER gene polymorphism may affect ER-mediated cardiovascular protective effect by modulating the expression of ER.

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