Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis

辛洪涛; 宋秀杰; 靳长俊; 王静; 黄琛; 张欣; 王建平; 姜淑娟

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Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis

Updated：2026-03-12

- Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis
- Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis
- 解放军医学杂志（英文版） 2003年第5期页码：2-300
- Affiliations：
  
  1. Department of Respiratory Medicine
  2. Shandong Provincial Hospital
  3. ,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（No.30271625）.
- DOI：
  中图分类号： R563.9
- 纸质出版：2003
- Accepted：
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Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis[J]. 解放军医学杂志（英文版）, 2003,(5):2-300.

[1]辛洪涛,宋秀杰,靳长俊,王静,黄琛,张欣,王建平,姜淑娟.Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis[J].Journal of Medical Colleges of PLA,2003(05):2-300.
Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis[J]. 解放军医学杂志（英文版）, 2003,(5):2-300. DOI：

[1]辛洪涛,宋秀杰,靳长俊,王静,黄琛,张欣,王建平,姜淑娟.Effect of expression of TGF-beta and TNF-alpha with Qidan granule treatment in rats by bleomycin-induced pulmonary fibrosis[J].Journal of Medical Colleges of PLA,2003(05):2-300. DOI：

摘要

Abstract

<正> Objective: To evaluate the therapeutic effects and mechanisms of Qidan granule in blemycinA5-induced pulmonary interstitial fibrosis （PIF）in rats. Methods: PIF models were established by blemycinA5-induced in rats. They were treated by Qidan granule and Hydrocortisone respectively. The pathological changes and collagen protein disposition were observed

and the expression of TGF-β

TNF-α proteins were measured by immunohistochemical technique . Results: The pulmonary alveolitis and fibrosis were alleviated remarkably in Qidan granule group compared with those in the model control group and hydrocortisone group （P <0. 01）. The expression of TGF-β and TNF-α protein were higher in Qidan granule group than those in normal group

and were significantly less than those in the model control group and in hydrocortisone group （P < 0. 01）. Conclusion: Qidan granule would ameliorate the pulmonary alveolitis and fibrosis. TGF-β and TNF-α might play an important role in the development of alveolitis and fibro

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