Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection

陈勇; 窦科峰; 何勇; 孙凯

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Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection

Updated：2026-03-12

- Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection
- Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection
- 解放军医学杂志（英文版） 2003年第4期页码：209-212
- Affiliations：
  
  1. Department of Hepatobiliary Surgery
  2. Xijing Hospital
  3. Fourth Military Medical University
  4. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R654.3
- 纸质出版：2003
- Accepted：
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Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection[J]. 解放军医学杂志（英文版）, 2003,(4):209-212.

[1]陈勇,窦科峰,何勇,孙凯.Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection[J].Journal of Medical Colleges of PLA,2003(04):209-212.
Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection[J]. 解放军医学杂志（英文版）, 2003,(4):209-212. DOI：

[1]陈勇,窦科峰,何勇,孙凯.Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection[J].Journal of Medical Colleges of PLA,2003(04):209-212. DOI：

摘要

Abstract

<正> Objective: To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis （AGA）

we established a mouse aorta graft model. Methods: A segment of thoracic aortas of B10. A （2R） mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological

histochemical and electro microscopic methods. Results: Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast

the endothelial inflammation and subsequent neointimal proliferation characteristic of AGA was localized to the regions of turbulent flow

i. e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejection and neointimal formation which usually manifested together in the lesion of AGA

elucidate that different mechanisms control vascular rejection and neointimal formation in chronic rejection.

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