Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori

屠振兴; 龚燕芳; 丁华; 许国铭; 李兆申; 满晓华

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Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori

Updated：2026-03-12

- Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori
- Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori
- 解放军医学杂志（英文版） 2003年第5期页码：286-289
- Affiliations：
  
  1. Department of Gastroenterology
  2. Changhai Hospital
  3. Second Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  National Natural Science Foundation of China （No.30170427）
- DOI：
  中图分类号： R573
- 纸质出版：2003
- Accepted：
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Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori[J]. 解放军医学杂志（英文版）, 2003,(5):286-289.

[1]屠振兴,龚燕芳,丁华,许国铭,李兆申,满晓华.Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori[J].Journal of Medical Colleges of PLA,2003(05):286-289.
Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori[J]. 解放军医学杂志（英文版）, 2003,(5):286-289. DOI：

[1]屠振兴,龚燕芳,丁华,许国铭,李兆申,满晓华.Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori[J].Journal of Medical Colleges of PLA,2003(05):286-289. DOI：

摘要

Abstract

<正> Objective: To study the relationship between nitric oxide synthase （ NOS） expression in human gastric mu-cosa and Helicobacter pylori （H. pylori） infection. Methods: Gastric mucosa samples were obtained from antrum of 33 patients received gastroendoscopy. H. pylori infection was confirmed by Giems staining and bacteria culture under mi-croaerophilic conditions. Expression of iNOS

eNOS and nitrotyrosine were detected by immunohistochemistry. Results: （1） The positive rate of H. pylori infection was 66. 7% （22/33） . （2） iNOS positive staining in inflammatory cells was detected in 77. 3% （17/22） of samples with H. pylori and 27. 3% （3/11） without H. pylori infection （P < 0.01）. （3） eNOS expression in inflammatory cells was found in 77. 3% （17/22） of samples with H. pylori and 18.2% （2/11） without H. pylori infection （ P < 0. 01） . （4） Nitrotyrosine expression in inflammatory cells was observed in 59. 1% （ 13/22） of samples with H. pylori and 54.5%（6/11） without H. pylori infection （P>0.05）. （5） Moderate a

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