Protective effect and mechanism of K<sub>ATp</sub> channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion

宋治远; 仝识非; 钟理

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Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion

Updated：2026-03-12

- Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion
- Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion
- 解放军医学杂志（英文版） 2003年第4期页码：205-208
- Affiliations：
  
  1. Department of Cardiology
  2. Southwest Hospital
  3. Third Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China （No. 30070314）
- DOI：
  中图分类号： R541.7
- 纸质出版：2003
- Accepted：
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Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion[J]. 解放军医学杂志（英文版）, 2003,(4):205-208.

[1]宋治远,仝识非,钟理.Protective effect and mechanism of K_(ATp) channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion[J].Journal of Medical Colleges of PLA,2003(04):205-208.
Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion[J]. 解放军医学杂志（英文版）, 2003,(4):205-208. DOI：

[1]宋治远,仝识非,钟理.Protective effect and mechanism of K_(ATp) channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion[J].Journal of Medical Colleges of PLA,2003(04):205-208. DOI：

摘要

Abstract

<正> Objective: To study the effect of KATp channel opener and its possible mechanism on the sinoatrial node cells of neonatal rats which were cultured under simulated ischemia-reperfusion. Methods: Freshly isolated sinoatrial node （SAN） cells of neonatal rats were purified and cultured for 2 d

and then they were randomly divided into the control

simulated ischemia-reperfusion group （I/R group）

group intervened with KATp channel opener pinacidil （P + I/R group）

KATP Channel blocking agent 5-HD （5-HD + I/R group）

and group with the 2 agents at same time （5-HD + P + I/R group） . The survival rate of cells was measured by flow cytometry and the content of intracellular calcium in the cells of each group was detected with laser confocal microscopy. Results: ① The survival rate of SAN cells in I/R group [ （51. 79±6. 28）% ] was remarkably significantly lower than in control [ （95. 08±10. 48）% ] （P < 0.001）

and very significantly lower than in P + I/R group [ （63. 77±5. 35） % ] （P<0.01）

however

those

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Protective effect and mechanism of KATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion

Protective effect and mechanism of KATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion

DOI：

摘要

Abstract

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references

Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion

Protective effect and mechanism of K_ATp channel opener on the sinoatrial node cells of neonatal rat cultured in simulated ischemia-reperfusion