<正>Objective: To study the effects of Salvia Miltiorrhiza Bge （SMB） on myocardial fibrosis in hypertension in rats. Methods: Normal Wistar kyoto rats served as negative control （group A） . The rats with hypertension were divided into 2 groups: the hypertension group （group B） which served as the positive control and the SMB-treated hypertension group （group C）. The effects of SMB on the systolic pressure

the myocardial content of aldosterone （ALD） and nitric oxide （NO） and the activity of superoxide dismutase （SOD） in the myocardium were detected. Results: The systolic pressure of the rats of group C showed no marked change after the administration of SMB and showed no difference from that of the rats of group B. The content of collagen Ⅰ and Ⅲ of the left ventricle

the collagen Ⅰ /collagen Ⅲ ratio and the content-of ALD were lower in group C than in group B and higher in group C than in group A. The content of NO and the activity of SOD in the myocardium were higher in group C than in group B and low