Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats

冯思哲; 魏学忠; 章翔

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Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats

Updated：2026-03-12

- Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats
- Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats
- 解放军医学杂志（英文版） 2004年第5期页码：278-281
- Affiliations：
  
  1. Department of Neurosurgery Xijing Hospital
  2. Fourth Military Medical University
  3. ,Shenyang,110016
  4. Department of Neurosurgery General Hospital of Shenyang Military Region
- Author bio：
- Funds：
- DOI：
  中图分类号： R363
- 纸质出版：2004
- Accepted：
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Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats[J]. 解放军医学杂志（英文版）, 2004,(5):278-281.

[1]冯思哲,魏学忠,章翔.Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats[J].Journal of Medical Colleges of PLA,2004(05):278-281.
Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats[J]. 解放军医学杂志（英文版）, 2004,(5):278-281. DOI：

[1]冯思哲,魏学忠,章翔.Contribution of spinal glia activation to mechanical hyperalgesia induced by spared nerve injury in rats[J].Journal of Medical Colleges of PLA,2004(05):278-281. DOI：

摘要

Abstract

<正>Objective: To investigate the role of spinal glial cells activation in neuropathic pain in a recently developed spared nerve injury （SNI） animal model by Decosterd and Woolf. Methods: A lesion was made to two of the three terminal branches of the sciatic nerve of rats （tibial and common peroneal nerves） leaving the sural nerve intact. Continuous intrathe-cal administration of propentofylline

a glial modulating agent

1 d before and 5 d after operation

was performed to disrupt spinal cord glia function. The vehicle was intrathecally administrated as control. The paw withdrawal threshold to mechanical stimulation （paw withdrawal mechaical threshold PWMT）

body mass and motor function were determined pre- and post-surgery. Results: It produced a prolonged mechanical allodynia in the medial and lateral part of the ipsilateral hind paw in SNL models. The treatment with propentofylline significantly prevented the development of mechanical allodynia located in either medial or lateral plantar surface. Rats in

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