Expression of PKD2 gene in human renal tissue and other tissues

周玉坤; 沈学飞; 梅长林; 汤兵; 孙田美; 宋吉

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Expression of PKD2 gene in human renal tissue and other tissues

Updated：2026-03-12

- Expression of PKD2 gene in human renal tissue and other tissues
- Expression of PKD2 gene in human renal tissue and other tissues
- 解放军医学杂志（英文版） 2004年第5期页码：293-296
- Affiliations：
  
  1. Department of Nephrology Changzheng Hospital
  2. Second Military Medical University
  3. Kidney Disease Center of PLA
  4. ,China
- Author bio：
- Funds：
  
  Supported by the 10th Five Year Plan Program for Major Sci-tech Foundation（No. 2002AAgZ3130）National INatural Science Founda- tion of China （No. 30170901, No.30271523）The Hundred Leading Scientists Program of the Public Health Sector of Shanghai （No. 97BR047）Major Basic Research Foundation of Shanghai Science and Technology Committee （No.02JC14029）
- DOI：
  中图分类号： R346
- 纸质出版：2004
- Accepted：
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Expression of PKD2 gene in human renal tissue and other tissues[J]. 解放军医学杂志（英文版）, 2004,(5):293-296.

[1]周玉坤,沈学飞,梅长林,汤兵,孙田美,宋吉.Expression of PKD2 gene in human renal tissue and other tissues[J].Journal of Medical Colleges of PLA,2004(05):293-296.
Expression of PKD2 gene in human renal tissue and other tissues[J]. 解放军医学杂志（英文版）, 2004,(5):293-296. DOI：

[1]周玉坤,沈学飞,梅长林,汤兵,孙田美,宋吉.Expression of PKD2 gene in human renal tissue and other tissues[J].Journal of Medical Colleges of PLA,2004(05):293-296. DOI：

摘要

Abstract

<正>Objective: To study the expression of PKD2 gene in human kidney and other tissues. Methods: The expression of PKD2 was detected by reverse transcription PCR（RT-PCR） and in situ hybridization（ISH） . The results of ISH were analyzed by micromegakargooytes. Results: Distribution of pkd-2 in normal adult kidney was stronger in proximal convoluted tubule

Henle’s loop ascending branch

distal convoluted tubule and cortical collecting ducts

and inferior signal were observed in fetal kidney. Negative was seen in ADPKD 2 kidney. Conclusion: Down-regulation of PKD2 gene expression in kidney may take effect on the occurrence and development of ADPKD2.

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