Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury

郝雪琴; 陶国才; 崔剑; 易斌; 陈毅飞

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Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury

Updated：2026-03-12

- Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury
- Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury
- 解放军医学杂志（英文版） 2006年第2期页码：122-124
- Affiliations：
  
  1. Department of Anesthesiology Southwest Hospital
  2. Third Military Medical University
  3. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R575
- 纸质出版：2006
- Accepted：
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Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury[J]. 解放军医学杂志（英文版）, 2006,(2):122-124.

[1]郝雪琴,陶国才,崔剑,易斌,陈毅飞.Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury[J].Journal of Medical Colleges of PLA,2006(02):122-124.
Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury[J]. 解放军医学杂志（英文版）, 2006,(2):122-124. DOI：

[1]郝雪琴,陶国才,崔剑,易斌,陈毅飞.Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury[J].Journal of Medical Colleges of PLA,2006(02):122-124. DOI：

摘要

Abstract

<正>Objective:To explore the protective effect of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury and their possible mechanism. Methods:The model of rat hepatic ischemia-reperfusion injury was used and the effect of remifentanil on the ultrastructure of mitochondria

calcium homeostasis

MDA level in mitochondria were observed. Results: In contrast with the control group

mitochondrial matrix calcium concentration

calcium concentration after calcium uptake

and the quantity of calcium uptake in low and high remifentanil concentration groups and 5-HD group are lower （P<0. 01）

and there is no difference in RHD （5-HD+remifentanil） group. The difference in MDA level between groups is insignificant. Conclusion:Remifentanil at clinical concentrations exerts a protective effect on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury

in which activating the KATP channel may be involved.

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