Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia

朱凌兰; 姜晓钟; 赵云富; 李玉莉; 何金

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Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia

Updated：2026-03-12

- Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia
- Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia
- 解放军医学杂志（英文版） 2004年第5期页码：307-310
- Affiliations：
  
  1. Department of Stomatology Changzheng Hospital
  2. Second Military Medical University
  3. ,China
  4. Department of Pathology Changzheng Hospital
- Author bio：
- Funds：
- DOI：
  中图分类号： R745.1
- 纸质出版：2004
- Accepted：
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Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia[J]. 解放军医学杂志（英文版）, 2004,(5):307-310.

[1]朱凌兰,姜晓钟,赵云富,李玉莉,何金.Expression of hNav1.8 sodium channel protein in affected nerves of patients with trigeminal neuralgia[J].Journal of Medical Colleges of PLA,2004(05):307-310.
Expression of hNav1. 8 sodium channel protein in affected nerves of patients with trigeminal neuralgia[J]. 解放军医学杂志（英文版）, 2004,(5):307-310. DOI：

[1]朱凌兰,姜晓钟,赵云富,李玉莉,何金.Expression of hNav1.8 sodium channel protein in affected nerves of patients with trigeminal neuralgia[J].Journal of Medical Colleges of PLA,2004(05):307-310. DOI：

摘要

Abstract

<正>Objective: To explore the pathogenesis of trigeminal neuralgia （TN） and to provide a new target for the drug treatment of TN by studying the expression of tetrodotoxin-resistant hNav1. 8 sodium channel protein in affected nerves of patients with TN. Methods: Twelve affected inferior alveolar nerves were obtained from patients with idiopathic TN

to whom the drug therapy was not effective. As negative control

one nonnal inferior alveolar nerve was obtained from patients who accepted the combined radical neck dissection with glossectomy and mandibulectomy. One muscle sample was obtained as normal control. One dorsal root ganglion from rat was as positive control. These tissues and prepared hNav1. 8 antibody were conducted immunohistochemistry response. Results: hNav1.8 channel protein was expresses in all the 12 specimens of the affected nerves of patients with TN

but not in the muscle sample and the normal inferior alveolar nerve. Conclusion: The abnormal expression of hNav1. 8 channel protein in the af

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