<正>Background: Recent data suggest that beta-blockers can be beneficial in patients with chronic heart failure （CHF）. Atrial fibrillation （AF） is present in a significant number of patients with CHF and is associateing with significant morbidity and increasing mortality rates. Thus it is necessary to establish therapy to improve the poor prognosis in this high-risk population

but a specific benefit of beta-blockers to the subset with concomitant AF and CHF has been little demonstrated. Objective: To examine the effects of Bisoprolol （6 months treatment） on the ventricular function and hemodynamics in patients with AF and CHF. Methods: 84 patients with stable CHF （NYHA≤Ⅲ class） and AF were assigned to Treated Group（ n = 37） or Control group Ⅰ （ n = 22

24-hour heart mean rate < 70/min） or Control Group Ⅱ （ n = 25

24-hour heart mean rate ≥ 70/min） . All patients were given the basic therapy for CHF

and Treated Group received Bisopolol. Clinical and echocardiographic variables were measured in 3 groups