A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts

邓艳春; 王吉村; 刘新平; 药立波

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A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts

Updated：2026-03-12

- A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts
- A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts
- 解放军医学杂志（英文版） 2004年第6期页码：342-345
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  中图分类号： R684.3
- 纸质出版：2004
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A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts[J]. 解放军医学杂志（英文版）, 2004,(6):342-345.

[1]邓艳春,,,,,,,,,王吉村,,,,,,,,,刘新平,,,,,,,,,药立波.A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts[J].Journal of Medical Colleges of PLA,2004(06):342-345.
A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts[J]. 解放军医学杂志（英文版）, 2004,(6):342-345. DOI：

[1]邓艳春,,,,,,,,,王吉村,,,,,,,,,刘新平,,,,,,,,,药立波.A novel tumor-suppressor candidate gene-ndr2 is differentially expressed between osteoarthritis synovium cells and rheumatoid arthritis synoviuni fibroblasts[J].Journal of Medical Colleges of PLA,2004(06):342-345. DOI：

摘要

Abstract

<正>Objective: To test whether the novel tumor-suppressor candidate gene-ndr2 is also differentially expressed between osteoarthritis synovium cells （OASC） and rheumatoid arthritis synovium fibroblasts （RASF）

and whether ndr2 can suppress the growth of RASF in vitro. Methods: Dot blotting

cell culture and gene transfection

cell cycle analysis techniques were applied to investigate the effect of ndr2 on the cell phenotype and cell cycles. Results: ndr2 is expressed in OASC but absent in RASF. Transient transfection of ndr2 into RASF can suppress the growth of RASF from phenotype observation. Cell cycle analysis showed that apoptotic peaks can be detected in RASF cells transfected with ndr2 gene. Conclusion: Novel tumor suppressor candidate ndr2 is not only differentially expressed between OASC and RASF but also can induce the apoptosis of RASF in vitro.

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