Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice

韩克起; 顾伟; 苏永华; 张亚妮; 黄雪强; 刘岭; 王喜; 凌昌全

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Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice

Updated：2026-03-12

- Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice
- Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice
- 解放军医学杂志（英文版） 2004年第6期页码：338-341
- Affiliations：
  
  1. Department of Tranditional Chinese Medicine
  2. Changhai Hospital
  3. Second Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China （No.30200364）
- DOI：
  中图分类号： R735.7
- 纸质出版：2004
- Accepted：
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Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice[J]. 解放军医学杂志（英文版）, 2004,(6):338-341.

[1]韩克起,顾伟,苏永华,张亚妮,黄雪强,刘岭,王喜,凌昌全.Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice[J].Journal of Medical Colleges of PLA,2004(06):338-341+345.
Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice[J]. 解放军医学杂志（英文版）, 2004,(6):338-341. DOI：

[1]韩克起,顾伟,苏永华,张亚妮,黄雪强,刘岭,王喜,凌昌全.Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice[J].Journal of Medical Colleges of PLA,2004(06):338-341+345. DOI：

摘要

Abstract

<正>Objective: To investigate anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. Methods: BEL-7402 cells of human hepatocellular carcinoma were inoculated to form subcutaneous tumors in nude mice by subcutaneous injection. Then the subcutaneous tumors were implanted into the liver of nude mice

and the orthotopic transplantation tumor models of human hepatocellular carcinoma were established. Seventy-five models were randomized into 5 groups （ n = 15） . Bufalin was injected intraperitoneally into the 3 groups at dose of 1.5

1 and 0.5 mg/kg for day 15 - 24

respectively. NS group were injected equal volume saline as above and adriamycin were injected intraperitoneally into ADM group at dose of 8.0 mg/kg for day 15. Ten mice in each group were killed at day 25 and detected on morphological and ultrastructural changes in myocardium

brain

liver

kidney and tumor tissues by pathology and electron microscope. The survival time in each group

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