Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia

张春利; 姚元庆; 李东红; 张伟

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Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia

Updated：2026-03-12

- Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia
- Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia
- 解放军医学杂志（英文版） 2006年第2期页码：117-121
- Affiliations：
  
  1. Department of Obstertrics and Gynecology Tangdu Hospital
  2. Fourth Military Medical University
  3. ,China
  4. Department of Pathology
- Author bio：
- Funds：
  
  Supported by the National Nature Science Foundation of China （No. 30070787）
- DOI：
  中图分类号： R321
- 纸质出版：2006
- Accepted：
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Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia[J]. 解放军医学杂志（英文版）, 2006,(2):117-121.

[1]张春利,姚元庆,李东红,张伟.Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia[J].Journal of Medical Colleges of PLA,2006(02):117-121.
Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia[J]. 解放军医学杂志（英文版）, 2006,(2):117-121. DOI：

[1]张春利,姚元庆,李东红,张伟.Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia[J].Journal of Medical Colleges of PLA,2006(02):117-121. DOI：

摘要

Abstract

<正>Objective: To investigate the altered expression of lipid metabolism-related gene adipose differentiation-related protein （ADRP） in pre-eclampsia. Methods: Semi-quantitative RT-PCR and Western blotting were used to validate the altered expression of ADRP gene between pre-eclamptic placentas （pre-eclampsia group） and normotensive placentas （control group） respectively. In situ hybridization （ISH） was used to localize ADRP mRNA in pre-eclamptic placentas. Results: There was a significant difference in the levels of placental ADRP mRNA between pre-eclampsia group and control group （1. 98±0. 50 vs 1. 09±0. 20

P<0. 01）. Western blotting showed that placentas both in pre-eclampsia group and control group expressed the special ADRP band at 48. 1 kD. The relative levels of ADRP protein in pre-eclampsia group were significantly higher than those of control group （0. 40 ±0. 19 vs 0. 19 ±0. 09

P<0. 01 ）. ADRP mRNA was diffusely distributed in pre-eclamptic placentas. Their positive staining existed in cytoplasm of trophoblast. Conclusion: Abnormal expression of ADRP gene in pre-eclamptic placenta may be associated with the pathogenesis of pre-eclampsia.

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