<正>Objective:To study the expression and its clinical significance of HLA-G in HCMV intrauterine infected placental villi at early pregnant stage. Methods:PCR （polymerase chain reaction） was used to screen the peripheral blood for HCMV-DNA in 462 women who had willingly undergone induced abortion. Then immunohistochemistry was also used to detect expressions of mouse anti-HCMV early antigen （HCMV-EA） and mouse anti-HLA-G in HCMV-DNA positive cases’ placental villi. The difference of HLA-G expressions between the intrauterine infection group （HCMV-EA positives）

the intrauterine infection-free group（HCMV-EA negatives） and the normal control group （SO cases of healthy early placental villi） was compared. Results: Of the 78 cases

which were detected HCMV-DNA positive

11 （14. 10%） were HCMV-EA positive. Compared with the other two groups

HLA-G expressions in the intrauterine infection group were both obviously decreased （both P<0. 001）. HLA-G expression positions in all three groups were mainly located in the cytotrophoblast. Conclusion:Intrauterine HCMV infection at early pregnant stage is closely related to HLA-G expression at the maternal-fetal interface. The virogenetic products may affect the expression of HLA-G at the maternal-fetal interface and that of its immunological function

thus leading to different clinical outcomes.