Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα

张莉莉; 祝之明; 曹廷兵; 王利娟

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Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα

Updated：2026-03-12

- Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα
- Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα
- 解放军医学杂志（英文版） 2006年第2期页码：77-81
- Affiliations：
  
  1. Department of Endocrinology Institute of Surgery Research
  2. Daping Hospital
  3. Third Military Medical University
  4. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R589.2
- 纸质出版：2006
- Accepted：
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Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα[J]. 解放军医学杂志（英文版）, 2006,(2):77-81.

[1]张莉莉,祝之明,曹廷兵,王利娟.Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα[J].Journal of Medical Colleges of PLA,2006(02):77-81.
Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα[J]. 解放军医学杂志（英文版）, 2006,(2):77-81. DOI：

[1]张莉莉,祝之明,曹廷兵,王利娟.Blockage of PPARδ increases the expression of inflammatory factors in 3T3-L1 cells stimulated with TNFα[J].Journal of Medical Colleges of PLA,2006(02):77-81. DOI：

摘要

Abstract

<正>Objective: To investigate the role of peroxisome proliferator-activated receptors δ （PPARδ） in inflammatory reaction and its possible mechanism in adipocyte. Methods :Lentivirus-mediated RNA interference （RNAi） was used to block the expression of PPARS in 3T3-L1 cells. In order to induce inflammation in 3T3-L1

cells were stimulated with tumor necrosis factor-α（TNFα

20 ng/ml） for 4 h. The expression of PPAR8

nuclear factor κB （NFκB） and C reactive protein （CRP） were determined by Western blot analysis. Results:The expression of PPARδ was reduced by 80% after RNAi. Blockage of PPARδ promoted the expression of CRP and NFκB in cells stimulated with TNFα

but had no effect on normal cells. Conclusion: PPARδ is involved in inflammatory reaction in adipocyte. Blockage of PPARδ can promote the inflammation mediated by inflammatory factors and increase the expression of NFκB and CRP in 3T3-L1 cells stimulated with TNFα.

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