<正>Objective: To assess the value of MR spectroscopy （MRS） in the diagnosis of prostate cancer by meta-analysis. Methods: Prospective studies were selected from the MEDLINE

Ovid

Embase databases. Springer

Elsevier

China National Knowledge Infrastructure. According to the suggestion

results were determined by the ratio of （Cho + Cr）/Cit . If this ratio was less than 0. 75

negative result was respectively determined

and the definitive tumor was diagnosed as this threshold. According to the assessment standard of Evidence-based Medicine

English and Chinese literature in Grade A and B on MRS imaging was included. According to homogeneity test

different effect models were chosen to calculate different pooled weighted values of sensitivity

specificity and the corresponding 95% confidence intervals (95% CD. Summary receiver operating characteristic （SROC） curves were used to assess the results. Funnel plot was used to analyze publication bias. Results: According to the assessment standard of Evidence-based Medicine

only 5 papers in Grade B were included in this research. The pooled weighted sensitivity and its 95% confidence interval is 82%（73%

89%） and the pooled weighted sensitivity and its 95% confidence interval is 68% （58%

76%）. The AUC （area under curve） is 83. 40%. An asymmetric funnel plot suggested two missing studies leading to publication bias. Conclusion: If the ratio of （Cho + Cr）/Cit is regarded as the diagnostic criteria in detecting prostate cancer by MRS

meta-analysis suggests this method has a better diagnostic value to detect the malignant prostate mass but the sensitivity needs to be improved. We hope to support a method and requirement about diagnostic test. Performing perspective register and improving quality of study design is the only way to reduce the bias and get real information of disease.