Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells

廖明芳; 景在平; 包俊敏; 赵志青; 梅志军; 陆清声; 崔佳森; 曲乐丰; 张素贞

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Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells

Updated：2026-03-12

- Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells
- Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells
- 解放军医学杂志（英文版） 2006年第2期页码：101-107
- Affiliations：
  
  1. Department of Vascular Surgery Changhai Hospital
  2. Second Military Medical University
  3. ,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 39800177）
- DOI：
  中图分类号： R543
- 纸质出版：2006
- Accepted：
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Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells[J]. 解放军医学杂志（英文版）, 2006,(2):101-107.

[1]廖明芳,景在平,包俊敏,赵志青,梅志军,陆清声,崔佳森,曲乐丰,张素贞.Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells[J].Journal of Medical Colleges of PLA,2006(02):101-107.
Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells[J]. 解放军医学杂志（英文版）, 2006,(2):101-107. DOI：

[1]廖明芳,景在平,包俊敏,赵志青,梅志军,陆清声,崔佳森,曲乐丰,张素贞.Nitric oxide production and inducible nitric oxide synthase protein expression in human abdominal aortic aneurysms and cultured aneurismal smooth muscle cells[J].Journal of Medical Colleges of PLA,2006(02):101-107. DOI：

摘要

Abstract

<正>Objective:To investigate the production of nitric oxide（NO） and the expression of indurible nitric oxide synthase （iNOS）. and their possible role in abdominal aortic aneurysm （AAA）. Methods: A total of 28 patients with AAA

10 healthy controls

and 8 patients with arterial occlusive disease were enrolled into this study. Standard colorimetric assay was used to examine NO concentration in plasma from patients with AAA and normal controls

and in cultured smooth muscle cells （SMCs）. Expression of iNOS in aortas and cultured SMCs were detected by immunochemistry. The correlation of iNOS expression with age of the patient

size of aneurysm

and degree of inflammation was also investigated by Cochran-Mantel-Haenszel X2 test and Kendall correlation. Results: Expression of iNOS increased significantly in the wall of aneurism in the patients with AAA compared to the healthy controls （P<0. 05） and the patients with occlusive arteries （P<0. 05）. iNOS protein and media NOx （nitrite + nitrate） also increased in cultured SMCs from human AAA （n = 4

P<0. 05）

while plasma NOx decreased in patients with AAA （n = 25） compared to the healthy controls （n = 20）. There was a positive correlation between iNOS protein and the degree of inflammation in aneurismal wall （Kendall coefficient = 0. 5032

P = 0. 0029）. Conclusion: SMCs and inflammatory cells are main cellular sources of increased iNOS in AAA

and NO may play a part in pathogenesis in AAA through inflammation

SMCs and oxidative stress.

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