Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats

王永堂; 鲁秀敏; 余瑛; 杨艳红; 高洁

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Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats

Original articles_Basic Medicine | Updated：2026-03-12

- Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats
- Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats
- 解放军医学杂志（英文版） 2007年第2期页码：92-96
- Affiliations：
  
  1. State Key Laboratory of Trauma Burns and Combined Injury Institute of Surgery Research
  2. Daping Hospital
  3. Third Military Medical University
  4. College of Bioengineering Chongqing Institute of Technology
  5. ,Chongqing,400050
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 30600665）;the Opening Project Foundation of State Key Laboratory of Trauma. Burns and Combined Injury （No. 2006A-3）;the Youth Scientific Research Foundation of Third Military Medical University （No.06XG048）
- DOI：
  中图分类号： R745.1
- 纸质出版：2007
- Accepted：
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Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats[J]. 解放军医学杂志（英文版）, 2007,(2):92-96.

[1]王永堂,鲁秀敏,余瑛,杨艳红,高洁.Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats[J].Journal of Medical Colleges of PLA,2007(02):92-96.
Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats[J]. 解放军医学杂志（英文版）, 2007,(2):92-96. DOI：

[1]王永堂,鲁秀敏,余瑛,杨艳红,高洁.Expression of NF-κB in Schwann cells and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in rats[J].Journal of Medical Colleges of PLA,2007(02):92-96. DOI：

摘要

Abstract

<正>Objective: To explore the expression of nuclear factor-kappa B （NF-κB） in Schwann cells （SCs） and its effect on motor neuron apoptosis in spinal cord following sciatic nerves injury in adult rats. Methods: Thirty-six adult Sprague-Dawley （SD） rats were divided randomly into normal control group （n=6）

and sciatic nerves crushing group （n=30）. and the later was further equally randomized into 5 subgroups: 1. 3. 7. 11. and 21 d post-injury groups. The expression of NF-κB of normal and injured nerves were examined by immunohistochemistry staining

and the apoptosis of motor neurons in spinal cord of lumbar 4 to lumbar 6 （L4-L6） was investigated by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling (TUNED assay. Both were quantitated by image analysis. Results: In crushing group

except 21 d post-injury group

the expression of NF-κB was markedly higher than that in the normal control group （P<0. 05

P<0. 01）. At 1 d after sciatic nerves crushing

the expression of NF-κB was obviously up-regulated

reached peak at 3 d. and recovered at 21 d. The same trend was observed in the time-course on motor neuron apoptosis after sciatic nerves injury. Correlation analyses revealed that motor neuron apoptosis was significantly and positively correlated with the expression of NF-κB following sciatic nerves injury （r=0. 976 0

P<0. 01）. Conclusion: After injury of sciatic nerves

the presence and up-regulation of NF-κB in SCs may be involved in motor neuron apoptosis in L4-L6 spinal cord.

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