The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells

陈宏颉; 郑兆聪; 王如密; 王手森; 杨卫忠

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The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells

Updated：2026-03-12

- The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells
- The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells
- 解放军医学杂志（英文版） 2006年第5期页码：307-311
- Affiliations：
  
  1. Department of Neurosurgery Fuzhou General Hospital
  2. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R739.4
- 纸质出版：2006
- Accepted：
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The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells[J]. 解放军医学杂志（英文版）, 2006,(5):307-311.

[1]陈宏颉,郑兆聪,王如密,王手森,杨卫忠.The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells[J].Journal of Medical Colleges of PLA,2006(05):307-311.
The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells[J]. 解放军医学杂志（英文版）, 2006,(5):307-311. DOI：

[1]陈宏颉,郑兆聪,王如密,王手森,杨卫忠.The effects of antisense PTEN gene transfection on the growth and invasion of glioma cells[J].Journal of Medical Colleges of PLA,2006(05):307-311. DOI：

摘要

Abstract

<正>Objective:To study the effects of antisense PTEN gene on the growth and invasion of glioma cells. Methods: A pcDNA3. 1/Hygro（-） recombinant plasmid containing antisense PTEN gene fragment was constructed. Glioma cells of primary culture were transfected with antisense PTEN gene vector and stably transfected clones were selected. Then

the different growth and invasion abilities and the different MMP9 mRNA expressions of three kinds of cells were observed

including the transfected cells

untrans-fected cells and the cells transfected with empty vector. Results:The abilities of growth and invasion of the transfected cells and the expressions of MMP9 mRNA were obviously enhanced. Conclusion: Antisense PTEN gene could have a negative impact on the growth and invasion of primary culture glioma cells.

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