Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats

焦亚斌; 芮耀诚; 李铁军; 杨鹏远; 邱彦

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Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats

Updated：2026-03-12

- Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats
- Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats
- 解放军医学杂志（英文版） 2006年第6期页码：347-351
- Affiliations：
  
  1. Department of Pharmacology School of Pharmacy Second Military Medical University
  2. ,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China （No. 30271509）
- DOI：
  中图分类号： R543
- 纸质出版：2006
- Accepted：
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Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats[J]. 解放军医学杂志（英文版）, 2006,(6):347-351.

[1]焦亚斌,芮耀诚,李铁军,杨鹏远,邱彦.Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats[J].Journal of Medical Colleges of PLA,2006(06):347-351.
Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats[J]. 解放军医学杂志（英文版）, 2006,(6):347-351. DOI：

[1]焦亚斌,芮耀诚,李铁军,杨鹏远,邱彦.Effects of ginkgo biloba extract on the expressions of IL-1β,TNF-α,IL-10 and IL-10R in heart of atherosclerotic rats[J].Journal of Medical Colleges of PLA,2006(06):347-351. DOI：

摘要

Abstract

<正>Objective: To study whether the anti-AS effect of ginkgo biloba extract （GbE） was related with inhibitory effects on the expression of IL-1β

TNF-αand up-regulation of IL-10 and IL-10R in the heart of atherosclerotic （AS） rats. Methods : The experimental model of AS rats were established by in-traperitioneal injection of vitamin D3 with high fat and cholesterol diet. All rats were divided into 3 groups: control

AS and GbE. GbE （100 mg/kg） was administered to rats by ig. After 8 weeks

the expression of IL-1β

TNF-α

IL-10

and IL-10R in the heart of AS rats were detected by enzyme-linked immunosorbant assay

reverse transcriptase polymerasechain reaction and Western blotting. Results:The protein and mR-NA expressions of IL-1β

TNF-α

IL-10 and IL-10R were markedly higher in AS group than those in control group （P<0. 01）. The protein and mRNA expressions of IL-1βand TNF-αwere markedly lower in GbE group than those in AS group; while the protein and mRNA expressions of IL-10 and IL-10R were markedly higher in GbE group than those in AS group （P<0. 01）. Conclusion: GbE has significant inhibitory effects on proinflammatory cytokine IL-1β

TNF-α. The up-regulation of anti-inflammatory cy-tokine IL-10

IL-10R that may be partially responsible for its anti-AS effects.

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