<正>Objective:To investigate serum levels of MMP 2

MMP-9.oxidized low-density lipoprotein （ox-LDL） in Alzheimer’s disease（AD） patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism.Methods:Subjects in this study were divided into 4 groups:normal lipid group without AD（N）

hyperlipoidemia group without AD（H）.normal group with AD（A）

hyper- lipoidemia group with AD（AH）.There were 15 individuals in each group.MMP-2

MMP 9

ox-LDL was measured by enzyme linked immunosorbent assay（ELISA）.Serum lipids levels were measured by biochemical methods.Results:The serum levels of MMP-2.MMP-9

ox-LDL were significantly higher in H.Aand AH groups than those in N group.Those of ox-LDL in H.AH groups was higher than that of in A group.The serum level of MMP 2

MMP-9 in AH groups were higher than that of in H group.The score of mini mental state examination （MMSE） in A and AD groups was negatively correlated with the serum level of ox-LDL.Relationship between the score of MMSE and the serum level of ox-LDI

in AD groups and non-AD groups had statistical significance.Conclusion:MMP-2

MMP-9

ox-LDL and abnor real lipid metabolism may participate in pathogenesis of AD

in which abnormal lipid metabolism induces expressions of MMP-2

MMP-9 and ox-LDL.Oxidative stress and blood-brain barrier disruption mighl ac- celerate the process of AD.