Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells

郭志良; 周跃; 李华壮; 曹国永; 滕海军

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Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells

Updated：2026-03-12

- Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells
- Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells
- 解放军医学杂志（英文版） 2006年第6期页码：379-382
- Affiliations：
  
  1. Department of Orthopedics Xinqiao Hospital Third Military Medical University
  2. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R363
- 纸质出版：2006
- Accepted：
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Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells[J]. 解放军医学杂志（英文版）, 2006,(6):379-382.

[1]郭志良,周跃,李华壮,曹国永,滕海军.Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells[J].Journal of Medical Colleges of PLA,2006(06):379-382.
Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells[J]. 解放军医学杂志（英文版）, 2006,(6):379-382. DOI：

[1]郭志良,周跃,李华壮,曹国永,滕海军.Role of calcium signaling in down-regulation of aggrecan induced by cyclic tensile strain in annulus fibrosus cells[J].Journal of Medical Colleges of PLA,2006(06):379-382. DOI：

摘要

Abstract

<正>Objective:To study the role of intracellular calcium signal pathway in the down-regulation of aggrecan induced by cyclic tensile strain in the annulus fibrosus cells. Methods:The expression of aggrecan mRNA and core protein were respectively detected with RT-PCR and western blot after the channels transmitting calcium ions were blocked with EGTA

gadolinium and verapamil. Results :EGTA. gadolinium and verapamil partially prevented the effects of cyclic tensile strain on the expression of aggrecan in annulus fibrosus cells. Conclusion:The calcium signaling is involved in the down-regulation of proteoglycan resulting from cyclic tensile strain in the annulus fibrosus cells.

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